Anticholingeric Agent. Theophylline competitively blocks phosphodiesterase which increases cAMP tissue concentrations causing bronchodilatation, diuresis, CNS and cardiac stimulation, and gastric acid secretion. Derivative Classification Training The purpose of this job aid is to provide quick reference information for the responsibilities and procedures associated with derivative classification. Anti-inflammatory. Bronchial dilation and increase focus of contraction of diaphragmatic muscle. Two xanthine derivatives with high affinity and high selectivity for adenosine A 1 receptor, 8-cyclopentyl-1,3-dipropylxanthine (DPCPX) (Lohse et al., 1987) and its analog 8-dicyclopropylmethyl-1,3-dipropylxanthine (KF15372) (Shimada et al., 1991), were selected as lead compounds for in vivo imaging. 152. Indications This job aid also provides an overview of the approved security classification documents that assist in analyzing and evaluating … Therapeutic Categories. The major pharmacologic actions of the xanthines are inhibition of tissue phosphodiesterases which i … Ipratropium Bromide administration. resulting from hydroxylation of Xanthine derivatives (uric acid derivatives) or demethylation products showed to be able to repair radicals resulting from adenine oxidation [12]. Mechanism of Action. Xanthine DerivativesXanthine derivatives such as theophylline inhibit phosphodiesterase, resulting in an increase in cAMP. Theophylline relaxes bronchial smooth muscle by inhibition of the enzyme phosphodiesterase and suppresses airway responsiveness to stimuli that cause bronchoconstriction. These are plant alkaloids and components of coffee, tea and chocolate. These medications open the airways, but they work on different receptors in the body. The xanthine derivatives are agents that resemble natural occurring xanthines such as caffeine, theobromine and methylxanthines. Chemical Formula. Xanthine Derivatives. The increase in cAMP causes relaxation of bronchial smooth muscle. As a member of the xanthine family, it bears structural and pharmacological similarity to theobromine … In the case of antipyrine derivatives demethylation reactions from the amino group induced by the hydroxyl radical were also … Xanthine derivatives Accession Number DBCAT001034 (DBCAT000503, DBCAT001028, DBCAT001220, DBCAT002203, DBCAT002692, DBCAT003295) Description. C5-H4-N4-O2. Xanthine CAS registry number (Chemical Abstracts Service) 0000069-89-6. Derivatives of xanthine (known collectively as xanthines) are a group of alkaloids commonly used for their effects as mild stimulants and as bronchodilators, notably in the treatment of asthma or influenza symptoms. Classifications of bronchodilators include beta 2-agonists, anticholinergics, and xanthine derivatives. In contrast to other, more potent stimulants like sympathomimetic amines, xanthines … Decrease inflammation. Molecular Weight. Clinical significance. Classification: Bronchodilator, Xanthine. Mast Cell Stabilizers. Inhalation and Intranasal spray. A methyl xanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Xanthine derivative Theophylline, also known as 1,3-dimethylxanthine, is a phosphodiesterase inhibiting drug used in therapy for respiratory diseases such as chronic obstructive pulmonary disease (COPD) and asthma under a variety of brand names. Pregnancy Category C Therapeutic actions. ... Ipratropium Bromide classification. 5.14 Xanthine Derivatives Open Resources for Nursing (Open RN) Theophylline is a xanthine derivative. 48:12.12 Xanthine Derivatives* 48:16 Expectorants 48:24 Mucolytic Agents* 48:36 Pulmonary Surfactants 48:48 Vasodilating Agents* 48:92 Respiratory Agents, Miscellaneous 52:00 Eye, Ear, Nose, and Throat (EENT) Preparations 52:02 Antiallergic Agents 52:04 Anti-infectives 52:04.04 Antibacterials 52:04.16 … Concentrations causing bronchodilatation, diuresis, CNS and cardiac stimulation, and gastric acid secretion resemble natural occurring such. Central nervous system stimulant activities as theophylline inhibit phosphodiesterase, resulting in an increase in cAMP causes relaxation of smooth... Relaxes bronchial smooth muscle, theobromine and methylxanthines these are plant alkaloids and components of coffee, and... 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